By Andrew J. Wyrobek (auth.), Andrew F. Olshan, Donald R. Mattison (eds.)
The reason for a number of the opposed reproductive results and developmental illnesses between offspring isn't good understood. many of the epidemiologic and experimental animal examine has excited about the connection among maternal exposures together with medicinal drugs, tobacco smoke, alcohol, infections, and career and the prevalence of spontaneous abortion, low delivery weight, and delivery defects. the capability function of paternal exposures has no longer been investigated as commonly regardless of long-standing animal learn that demonstrates the induction of mutations within the male germ mobilephone after publicity to definite brokers and next reproductive failure or early being pregnant loss. Given this relative loss of curiosity, acquisition of epidemiologic information and the advance of a definitive version or mechanism for capability male-mediated results has been hindered. notwithstanding, contemporary laboratory and epidemiologic investigations have instructed that paternal exposures will be extra vital than formerly suspected. This subject has been termed by way of a few as "male-mediated developmental toxicity. " this is often intended to consult the consequences of exposures and different components in relation to the male dad or mum that bring about toxicity to the conceptus and irregular improvement. The developmental endpoints of curiosity can comprise fetal loss, congenital abnormalities, development retardation, melanoma, and neurobehavioral results. those results might function via a number of mechanisms together with gene mutation, chromosomal aberrations, seminal fluid move of toxicants and epigenetic events.
Read Online or Download Male-Mediated Developmental Toxicity PDF
Best nonfiction_8 books
Growth of Crystals: Volume 16 - download pdf or read online
Papers from the 6th All-Union convention on progress of Crystals contain quantity sixteen of this sequence. The articles have been selected so that it will extra absolutely elucidate the elemental difficulties of crystal progress as mirrored in family and overseas experiences and in unique reviews. This quantity comprises six components.
Download e-book for iPad: Brand Communities for Fast Moving Consumer Goods: An by Sandra Meister
Do model groups particularly paintings for FMCG? Can shoppers inquisitive about model groups be characterised by means of particular behavioral attributes? Are there major modifications among participants and people shoppers who're easily traveling the brand-community web site? And do the individuals express the next point of purchaser retention as these non-member?
Being either large - belief and motor association - and slim - simply onegroup of animals - while, this publication provides a brand new unified framework for figuring out perceptuomotor association, stressing the significance of an ecological viewpoint. part I reports fresh examine on a number of sensory and perceptual methods in birds, which all contain refined analyses of the relationships among species' perceptual mechanisms and their ecology and behavior.
- The Dynamic Structure of Cell Membranes
- Perspectives in Ethology: Volume 7 Alternatives
- Optimal Domain and Integral Extension of Operators: Acting in Function Spaces
- The Solar Engine and Its Influence on Terrestrial Atmosphere and Climate
- Purines in Cellular Signaling: Targets for New Drugs
Additional resources for Male-Mediated Developmental Toxicity
Sample text
The length of time required for specific spermatogenic cells to develop and appear in the ejaculate have been delineated in classical studies (Oakberg, 1984). Thus, offspring that trace to paternal exposures during specific spermatogenic stages can readily be identified on the basis of the interval between exposure and conception. Offspring conceived in the first seven post-treatment weeks are, successively, derived from exposed spermatozoa, late spermatids, early spermatids, diplotene and late pachytene spermatocytes, early pachytene and leptotene spermatocytes, late differentiating spermatogonia, and early differentiating spermatogonia.
Dickie (1967) Spontaneous mutations and mutation rates in the house mouse. Genetics 57, 319-330. Schlager, G. M. Dickie (1971) Natural mutation rates in the house mouse: Estimates for five specific loci and dominant mutations. Mutation Res. 11, 89-96. Scarle, AG. (1974) Mutation induction in mice, in: "Advances in Radiation Biology, Vol. T. 1. Adler, and M. ), Academic Press, New York. pp. 131-207. Searle, AG. J. de Serres and W. ), Plenum, New York, pp. 279-288. Searle, AG. (1986) The role of dominant visibles in mutagenicity testing.
Trends Genet. 1, 100-103. E. Housman (1988) The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55, 185-192. T. V. Cornett (1985) 239 Plutonium-induced heritable translocations in male mice. Mutation Res. 152,49-52. T. V. A. A Hughes (1990) Concentrationresponse curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations. Environ. Mol. Mutagen. 16, 126-13l. , J. Lane and D. Houseman (1990) A mouse model for the Aniridia-Wilm'sTumor deletion syndrome.
