By G. Bucossi, M. Nizzari, V. Torre (auth.), Vincent Torre, Franco Conti (eds.)
Understanding how the mind works is absolutely the best problem for human intelligence and probably the most formidable ambitions of up to date technology. we're definitely faraway from this aim, yet major developments in numerous fields of Neuroscience and Neurobiology are being acquired at an expanding speed. The NATO ASI institution in Neurobiology, held in Erice may well 2-12,1995, because the twenty third process the overseas tuition of Biophysics, supplied an replace on 3 uncomplicated issues: Biophysics and Molecular Biology ofIon Channels, Sensory Transduction, and better Order features. present wisdom on those topics was once lined by means of formal lectures and important discussions among academics and individuals. This e-book collects unique contributions from these scientists who attended the varsity. Many scholars offered their leads to poster periods, steerage vigorous casual discussions. a variety of those contributions can be integrated. an immense component of this system of the college used to be dedicated to a basic assessment of present tendencies of concept and experimental methods in neurobiology, emphasising the significance of figuring out molecular facets of the effortless occasions underlying sensory transduction and processing within the apprehensive approach, with out indulging although in a natural reductionistic view of such complicated phenomena. fresh experiences of molecular biology and the electrophysiology of heterologously expressed ionic channels, have shed new mild at the molecular mechanisms underlying ionic permeation of excitable membranes and its rules through actual and chemical parameters.
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Nature 369, 336-339. Nishizuka, Y. (1995). Protein kinase C and lipid signalling for sustained cellular responses. FASEB Journal 9, 484-496. O'Dell, T. J. & Alger, B. E. (1991). Single calcium channels in rat and guinea-pig hippocampal neurons. Journal of Physiology 436, 739-767. , Polio, A.. Carbone, E. & Sher, E. (1994). w-Conotoxin and Cd 2 + stimulate the recruitment to the plasmamembrane of an intracellular pool of voltage-operated Ca 2 +channels Neuron 12,317-326. , Socci, C. & Carbone, E.
1991). A regulatory action of endogenous ~-subunits on the G protein/Ca 2+ channel coupling has been also suggested by experiments on Ca2+ channel current modulation in sensory neurons using antisense oligonucleotide against ~-subunits (Berrow, Campbell, Fitzgerald, 30 E. Carbone et aI. Brickley & Dolphin, 1995). Cell pre-treatment with ~-subunits antisense caused a marked Ca2+ current decrease in rat DRGs. The reduced currents (N- and L-type), however, were inhibited by GABA B receptors activation more potently than control currents, suggesting competitive interaction between activated Ga-subunits (or G~y) and the Ca2+ channel ~-subunit for an intracellular site of the channel aI-subunit.
1991) GABAb receptor-mediated inhibition of Ca 2+ currents and synaptic transmission in cultured rat hippocampal neurones. Journal of Physiology. 444, 669-686. Schroeder, 1. , Fischbach, P. S. & McCleskey, E. W. (1990). T-type calcium channels: heterogeneous expression in rat sensory neurons and selective modulation by phorbol esters. Journal ofNeuroscience 10, 947 -95\. 40 E. Carbone et al. , Silberberg, S. , Ginsburg, S. & Rahaminoff, R. (1987). Activation of protein kinase C augments evoked transmitter release.
