By J. Kiefer (auth.), Prof. Dr. Jürgen Kiefer (eds.)
Radiation is the only agent between all environmental elements that can harm organic platforms that's not in simple terms simply quantifiable yet is also measured with unsurpassed answer. Its basic results on atoms and molecules are good understood, and the secondary approaches could be by way of subtle experimental innovations. The quantum nature of interactions and the significance of stochastic adaptations demand a precise mathematical description. This job is under no circumstances basic, and offers a problem either to the experimentalist and to the theoretician. it really is was hoping often appropriate formalism can assist to quantify radiation responses, either in radiation safety and radiation remedy, and give the opportunity to maneuver from a simply empirical procedure with all its fallacies to actual understanding.
Read or Download Quantitative Mathematical Models in Radiation Biology: Proceedings of the Symposium at Schloss Rauisch-Holzhausen, FRG, July 1987 PDF
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Additional info for Quantitative Mathematical Models in Radiation Biology: Proceedings of the Symposium at Schloss Rauisch-Holzhausen, FRG, July 1987
Example text
LET - even if used in its restricted form - is not sufficient to describe the effects of radiation quality. It is not even unequivocal because it depends both on charge and velocity. There are many examples that different particles having the same LET show quite different biological effects. The reason for this lies in the fact that not only energy deposition along a particle's path is important but also around it, with other words, track structure. This was soon realized and led to the creation of new scientific subdiscipline, microdosimetry.
Radiat. Res. M. , 1972, The theory of dual radiation action. Curro Top. Radiat. Res. Q8, pp85-158. M. , 1978, A generalized formulation of dual radiation action. Radiat. Res. 75, pp471-488. , 1980, Concepts of geometrical probability relevant to microdosimetry. Proc. 7th Symp. G. , pp1049-1062. Kiefer J. , 1986, A model of ion track structure based on classical collision dynamics. Phys. Med. BioI. 31, pp1201-1209. G. , 1976, Measurement of radial energy deposition spectra for protons and deuterons in tissue-equivalent gas.
Furthermore, more extensive studies on these, not cited here, have shown that further subdivision of these elements is possible, suggesting that at least eight different physicochemical kinds of events leading to cell death are experimentally available in this system. So the initial proposition above that the elemental construction of the radiation response must be included in any algebraic analysis of experimental numbers is justified. We demonstrate that in this dry system (in which early events are more readily available for manipulation by the experimentalist) there are independently operating kinds of radiation damage that must be considered, each separately from the others.
