Base Excision Repair by Kivie Moldave, Sankar Mitra, Amanda K. McCullough, R. PDF

By Kivie Moldave, Sankar Mitra, Amanda K. McCullough, R. Stephen Lloyd, Samuel H. Wilson (Eds.)

This quantity of growth in Nucleic Acid study and Molecular Biology represents learn mentioned throughout the DNA Base Excision fix Workshop. This compilation of articles specializes in a number of contemporary observations highlighting the complexity of the bottom excision fix (BER) approach in DNA fix. concentrating on a number of the points of BER learn, this e-book is a well timed and hugely priceless reference for investigators within the DNA fix box. it is going to additionally reduction scientists in some way interested by fix experiences to procure a entire knowing of the present nation of data within the box.

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IET AL. aldehyde of an AP site (29) which results in a stably adducted sugar molecule (30) (Fig. 2). In 1991, by using a synthetic oligonucleotide containing a single MX-modified AP site, we showed that this modification changed the substrate specificity of different AP endonucleases (31). While endonuclease III and endonuclease IV of E. coli were able to cleave the alkoxyamine-adducted site, a HeLa AP endonuclease and chide cell extracts were inhibited by this modification. This topic has recently been reanalyzed (32).

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