Download e-book for kindle: Comparative Biology of Aging by Norman S. Wolf

By Norman S. Wolf

Made up our minds by way of an lack of ability to maneuver in accordance with contact. C. elegans strengthen via 4 larval phases following hatching and sooner than maturity. grownup C. elegans are reproductive for approximately the rst week of maturity through nearly weeks of post-reproductive maturity sooner than demise. existence span is most typically measured within the laboratory by means of conserving the worms at the floor of a nutrie- agar medium (Nematode development Medium, NGM) with E. coli OP50 because the bacterial nutrients resource (REF). substitute tradition stipulations were defined in liquid media; in spite of the fact that, those aren't typical for sturdiness stories. durability of the widely used wild kind C. elegans hermaphrodite (N2) varies ? from sixteen to 23 days less than regular laboratory stipulations (20 C, NGM agar, E. coli OP50 foodstuff source). existence span could be elevated through conserving animals at reduce ambient temperatures and shortened by means of elevating the ambient temperature. Use of a killed bacterial nutrients resource, instead of reside E. coli, raises lifespan by way of 2–4 days, and progress of grownup animals within the absence of micro organism (axenic progress or bac- rial deprivation) raises median lifestyles span to 32–38 days [3, 23, 24]. less than either usual laboratory stipulations and bacterial deprivation stipulations, wild-derived C. elegans hermaphrodites show sturdiness equivalent to N2 animals [25]

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Mech Ageing Dev 6(6): 413–429. 37. Garigan D et al. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation. Genetics 161(3): 1101–1112. 38. Garsin DA et al. (2003). Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300(5627): 1921. 39. Bauer JH, Goupil S, Garber GB, and Helfand SL (2004). An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.

This chapter will discuss the history of ideas about the mechanisms underlying the relationship between body size, health, and longevity and try to bring some coherence to what is known about this relationship at present. First, it is convenient to dichotomize the discussion into size-health-longevity patterns between species – the interspecific pattern – such as horses versus dogs versus mice and patterns within species – the intraspecific pattern – such as small dogs versus large dogs, horses versus ponies, or one mouse genotype versus another.

Small birth size or neonatal size due to maternal undernutrition has been linked to a range of late life diseases [39], but nutritional restriction in early life has also been linked to improved health and longer life [40]. So this issue is obviously pretty complicated, may differ among species, and may subtly depend on the nature, degree, and timing of undernutrition. Also, some size differences represent natural variation within a species, but more of what we know about size and longevity comes from strains or breeds that have been purposefully bred by humans to be different in size.

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