By Prasanti Babu, Anuj K. Chandel, Om V. Singh
Extremophiles are recognized to thrive less than harsh environmental stipulations. Many extremophilic bio-products are already used as life-saving medicines. contemporary technological developments of platforms biology have opened the door to discover those organisms anew as resources of goods that would end up precious in medical, environmental and drug development.
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Extra info for Extremophiles and Their Applications in Medical Processes
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1 summarizes the therapeutic implications of the substances that can be derived from extremophiles. © The Author(s) 2015 P. 1007/978-3-319-12808-5_3 25 Role in disease types Prevents Alzheimer’s and Parkinson’s diseases from developing; Prevents damage from bone marrow and protects skin from exterior radiations; prevent skin damage due to from UVR; Skin cancer, etc. Treat misfolded proteins: aid in curing neurodegenerative diseases; thermolytes: used in protein degradation; suppress cancer activity: known to aid in T cell proliferation of leukocytes; antitumor suppression Prevent multiple cancer types; chronic inflammation; atherosclerosis; cardiovascular disorder; aging process; Types of extremophile Radiationresistant Thermophiles Halophiles Stable proteins; thermosomes, (chaperone protein), act as a facilitator and maintain the rest of the chaperone proteins for the cell; stable amylases; thermozymes are being produce in surrogate mesophilic hosts; enzymes and proteins from the genus Thermus, and thermozymes in general are good candidates for biocatalytical processes as they often present higher operational stability, and enhanced co-solvent compatibility Reductase from H.
2014). Further, due to recent developments in genome sequencing techniques, much of the research has been on developing hypotheses related to the Fig. 3 Extremophiles Like Other Organisms 41 genomics data and little has been done to test these hypotheses. Baker-Austin and Dopson (2007) highlighted the need for genetic tools to perform in-depth analysis of the genetic and biochemical foundations of the observed phenomena and defensive mechanisms. Another technological challenge in developing extremophiles is the specific peculiarities of these organisms, which are extremely difficult to replicate in a natural environment.
Cell Stress Chaperones 10:197–203 Cárdenas JP, Valdés J, Quatrini R et al (2010) Lessons from the genomes of extremely acidophilic bacteria and archaea with special emphasis on bioleaching microorganisms. Appl Microbiol Biotechnol 88:20–605 Castanie-Cornet MP, Penfound TA, Smith D et al (1999) Control of acid resistance in Escherichia coli. J Bacteriol 181:3525–3535 Cava F, Hidalgo A, Berenguer J (2009) Thermus thermophilus as biological model. Extremophiles 13:213–231 Cavicchioli R, Amils R, Wagner D et al (2011) Life and applications of extremophiles.
