By Medha N. Munshi, Lewis A. Lipsitz
The variety of aged sufferers with diabetes is expanding at an important expense. Responding to this progress, this resource serves as an effective arsenal of knowledge at the various shows and demanding situations linked to diabetes within the geriatric sufferer, and offers basically written sections at the screening, prognosis, and therapy of diabetes in aged populations. With contributions from popular gurus from the nationwide and overseas associations, this reference will depict the function of particular co-morbidities, socioeconomic elements, and caregiver concerns at the powerful administration of diabetes within the older grownup.
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Eur Cytokine Netw 2006; 17(1):4–12. 168. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006; 116(7): 1793–1801. 169. de Maat MP, Bladbjerg EM, Hjelmborg JB, Bathum L, Jespersen J, Christensen K. Genetic influence on inflammation variables in the elderly. Arterioscler Thromb Vasc Biol 2004; 24(11):2168–2173. 170. de Craen AJ, Posthuma D, Remarque EJ, van den Biggelaar AH, Westendorp RG, Boomsma DI. Heritability estimates of innate immunity: an extended twin study.
48. Tsuchiya T, Schwarz PE, Bosque-Plata LD, et al. Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006; 89(1–2): 174–184. 49. Weedon MN, Schwarz PE, Horikawa Y, et al. Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 2003; 73(5): 1208–1212. 50. Wang Y, Xiang K, Zheng T, Jia W, Shen K, Li J. The UCSNP44 variation of calpain 10 gene on NIDDM1 locus and its impact on plasma glucose levels in type 2 diabetic patients.
Increased dietary iron may be associated with an increased risk of diabetes in aged individuals (13,15). Chromium deficiency has been found to cause abnormal glucose metabolism in younger patients, but as yet, no studies have shown a 30 Meneilly FIGURE 1 Factors contributing to the high prevalence of diabetes in the elderly. similar effect in the elderly. Obesity, especially with a central distribution of body fat, and a reduction in physical activity occur progressively with aging, and both of these factors are associated with abnormal carbohydrate metabolism (10,12,16–19).
