By Eric Le Bourg, Suresh I.S. Rattan
Stress is a double edged sword. while persistent rigidity has renowned damaging results, fresh learn exhibits that intermittent publicity of cells and organisms to gentle rigidity can increase numerous organic parameters, together with critical rigidity tolerance, healthiness span and durability. gentle stress-induced hormesis is in all likelihood a strong instrument in gerontological learn and interventions. This ebook brings jointly a number of the global leaders during this quarter of study who current a serious research of the continuing examine with appreciate to the consequences and mechanisms of motion of varied forms of gentle tension, akin to irradiation, warmth, physical exertion, hypergravity, pro-oxidants and dietary elements, on a number of organic structures starting from fruitflies to human cells and our bodies. Their separate chapters and a last collective bankruptcy open up a complete new international of probabilities for destiny examine in getting older, winning getting older, and overall healthiness span extension.
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Extra info for Mild Stress and Healthy Aging: Applying Hormesis in Aging Research and Interventions
Sample text
It has been shown that protecting from natural ionizing radiation delayed development of fruit flies (Planel et al. 1967a), decreased reproductive performance (Planel et al. 1967b) and life span (Giess and Planel 1973; Planel and Giess 1973). In the last study, two populations of D. melanogaster were compared. The control group experienced the normal ambient radiation exposure, while the experimental group, from egg to death, experienced 10% of the natural gamma ray background irradiation. 4% (Planel and Giess 1973).
A residuum of unrepaired toxicity (injury) appeared to persist and manifest itself throughout life. A second response, longevity hormesis, was also observed. Detrimental Effects of Suppressing Background Radiation Numerous facts indicating that background ionizing radiation may be essential for life provided a strong argument in favor of a beneficial effect of low level radiation. 5 billion years ago was about three times higher than now (Jaworowski 1997). Indeed, exposure to lower than natural radiation has been shown to cause deficiency symptoms in protozoa and bacteria.
Memorandum. RM–5083–TAB. The Rand Corporation, Santa Monica, CA Brucer M (1990) A Chronology of Nuclear Medicine, Heritage Publications, St. Louis Cai L and Wang P (1995) Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic gamma-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring. Mutagenesis 10: 95–100 Calabrese EJ and Baldwin LA (2000) Radiation hormesis: its historical foundations as a biological hypothesis.
