By Arthur M. Jr. Dannenberg
Examines the pathogenesis of human pulmonary tuberculosis in all of its levels, with a main specialize in the rabbit version.
• experiences the interaction of delayed-type hypersensitive reaction and cell-mediated immunity, sincerely displaying how either are had to regulate the expansion of the tubercle bacillus and the way antibodies give a contribution to those mobile immune responses.
• Covers the histochemistry of macrophage activation; the jobs of varied cytokines; the results of glucocorticoids, estrogens, thyroid hormones, and irradiation at the affliction; and ideas of immunization opposed to tuberculosis, together with vaccine improvement.
• specializes in parts of destiny learn which may give a contribution to the data, remedy, and keep watch over of this illness.
• Serves as a source for clinicians, public healthiness investigators, and laboratory researchers in tuberculosis and immunology.
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Extra info for Pathogenesis of human pulmonary tuberculosis : insights from the rabbit model
Example text
Rodrigue, J. Beaucher, L. Gaudreau, and I. Smith. 2004. Sigma factors and global gene regulation in Mycobacterium tuberculosis. J. Bacteriol. 186:895–902. Dannenberg, A. , M. S. Burstone, P. C. W. Kinsley. A histochemical study of phagocytic and enzymatic functions of rabbit mononuclear and polymorphonuclear exudate cells and alveolar macrophages. I. Survey and quantitation of enzymes, and states of cellular activation. J. Cell Biol. 17:465–486. , J. W. Senner, W. T. Reddick, and J. P. Lofgren.
STAGES OF HUMAN AND RABBIT TUBERCULOSIS FIGURE 1 Stage 1. , high levels of lysosomal and oxidative enzymes. Most alveolar macrophages are nonspecifically activated by the variety of inhaled particles that they ingest. In humans, an alveolar macrophage is usually able to kill an inhaled tubercle bacillus, except when the bacillus is unusually virulent or the macrophage is poorly activated. Reproduced with permission from reference 4. Ⅵ 23 viable bacilli than did the lungs of his inbred resistant rabbits (7, 8) (Fig.
70:5568–5578. 29. Manabe, Y. , C. P. Scott, and W. R. Bishai. 2002. Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine is better than subcutaneous Mycobacterium bovis BCG. Infect. Immun. 70:1566–1570. 30. Behr, M. , and P. M. Small. 1999. A historical and molecular phylogeny of BCG strains. Vaccine 17:915–922. 31. Behr, M. , M. Wilson,W. P. Gill, H. Salamon, G. K. Schoolnik, S. Rane, and P. M. Small. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray.
