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For new chemicals with no measurement data at all, rough estimations of exposure are necessary. Some chemical agents are of concern because they are present in foods or may be absorbed when a consumer product is used. Assessments of exposure to such agents are complicated by variations in diet and personal habits among different groups in the population. Even when the amount of an agent in a food can be measured, differences in food storage practices, food preparation, and dietary frequency often lead to a wide variation in the amount of the agent that individuals ingest.

Risk assessments comprise many or all of the following steps: hazard identification, dose-response assessment, exposure assessment, and risk characterization. Components. Steps in risk assessment comprise many components—points in a risk assessment at which judgments must be made regarding the analytic approach to be taken. Inference options. For many components, two or more inference options are available. Risk Assessment Policy. Risk assessment policy consists of the analytic choices that must be made in the course of a risk assessment.

Please use the print version of this publication as the authoritative version for attribution. THE NATURE OF RISK ASSESSMENT 39 Agenda-setting involves decisions about which substances should be selected (and often in what order) for more intense formal regulatory review. All programs face this problem, but it assumes different configurations: some programs cover a finite and known set of chemicals that must be reviewed, so the order of the regulatory reviews is the key question, and the primary job of the risk assessor is to help the agency implement a worst-first approach.

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