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Additional info for Toxicological profiles - Radon
Example text
No information on neurological effects in humans exposed to radon was located in the available literature. Only one animal study attributed the toxic effects observed to the action of radon on the central nervous system. 4) that limit its usefulness and render the reported results questionable. Reproductive Effects. Recent epidemiological studies have raised speculation that inhalation exposure to radon and radon daughters during uranium mining may be associated with effects on reproductive outcome.
The extent and severity of the hematological effects were related to the level of exposure and the exposure duration, and red blood cells appear to be more sensitive to the effects of radon than white blood cells. Following acute exposure by the inhalation or intravenous routes, decreases in the number of red blood cells and white blood cells occurred immediately post-exposure. Red blood cells remained depressed for the remaining life of the treated animals, while white blood cells returned to normal levels post-exposure.
However, the cause of this decreased lifespan was not reported. The authors then sacrificed the remaining animals (15 treated mice and 3 control mice) for purposes of histopathological examination. Tracheal effects, including thickening of the mucous membrane, inflammation of the mucous glands, and destruction of cells lining the trachea, were observed. However, the onset of these effects could not be determined. In Morken (1973), mice and dogs were exposed to radon for intermediate periods of time and then sacrificed at 5 7 3 designated times post-exposure.
