By Bruno Antonny, Michel Roux, Marc Chabre (auth.), Demetrios A. Spandidos (eds.)
since the earliest effects at the linkage among ras activation and mobilephone transformation seemed an enormous volume of extra details has been generated which emphasizes the significance of ras-related genes in membrane trafficking, mobilephone proliferation, differentiation and melanoma. those advances ended in the advance of recent suggestions for the analysis, diagnosis and prevention of melanoma. Ras-related genes seem to be vital to the mechanism of transformation by way of different oncogenes and for that reason represent a focus upon which makes an attempt to interfere within the strategy of carcinogenesis could be targeted. the current quantity includes the contributions to the NATO complicated examine Workshop at the "The Superfamily of ras-Related Genes" held in Agia Pelagia, Heraklion, Crete, Greece, could 1991. At this assembly the prime researchers during this box carne jointly to debate the latest growth in research of organic functionality of the ras-related genes. As an organizer i think that the Workshop was once successful, and want to thank all of the members and the participants to this quantity. I thank the NATO medical Affairs department, Brussels, the Greek Ministry of undefined, power and expertise, the overseas heart for melanoma examine, the nationwide Hellenic examine starting place and the clinical tuition, college of Crete for sponsoring the Meeting.
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M. (1987) Biochern. Biophys. Res. -P. Y. (1988) Oncogene Res. , Rielh, R. A. (1989) Proc. Acad. Sci. J. L. (1989) Mol. Cell. , shirataki, H. and Takai, Y. (1991) 1. Bioi. Chern. 266, 6571-6577 39 REGULATION OF THE RAS PATHW AY IN THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE David A. Hughes, Yoshiyuki Imai and Masayuki Yamamoto. Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Tokyo 113, Japan INTRODUCTION Homologs of the mammalian ras genes have been found in the simple unicellular yeasts Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast) (reviewed in Gibbs and Marshall, 1989).
Rap 1 proteins were phosphorylated only when PKA was stimulated by 8-Br-cAMP (figure 4B, lanes 2 and 7); although the extent of phosphorylation was somewhat lower in quiescent cells, it appears that the sites for PKA were available under both conditions. 345678 Figure 4. Phosphorylation of the rap 1 protein in quiescent and proliferating cells. Panel A: Bromodeoxyuridine incorporation into Rat-l cells at different states of growth was assayed by immunofluorescence using a commercial kit (Amersham).
A c k now led g men t s: This work was supported by grants from the INSERM, the Association pour la Recherche contre Ie Cancer and the Ligue Nationale contre Ie Cancer. L. is the recipient of a fellowship from the Ministere de Ia Recherche et de la Technologie. , Olofsson, B. and Tavitian, A. , Chardin, P. and Tavitian, A. (1988) Nucleic Acids Res. , Teranishi, Y. and Takai, Y. (1988) J. Bioi. Chern. , Clemetson, KJ. G. (1990) Proc. Natl. Acad. Sci. USA 87, 6527-6531 5- Barbacid, M. (1897) Annu.
