By K. C. Nicolaou, Rudolf Hanko, Wolfgang Hartwig
In the end, the mechanism-based and application-oriented guide of combinatorial chemistry.Since its very starting, examine during this box has endured to strengthen at a quick expense. more and more stylish equipment are being invented and a fair wider variety of attainable purposes remains to be being chanced on, such that combinatorial chemistry is now a vital part of commercial and educational research.The high-class editorial workforce - ok. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - make certain complete assurance and firstclass contributions. This two-volume paintings bargains with artificial chemistry in all its varieties, purposes from existence sciences, chemistry andmaterial sciences, all there's to grasp approximately compound library layout and synthesis, and, after all, the overall fundamentals - making it an imperative reference for man made, natural and medicinal chemists, chemical biologists in addition to fabric scientists.
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Additional info for Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials (2-Vol. Set)
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2 Brief History of Combinatorial Chemistry Australia prepared a library of peptides [9] on functionalized polypropylene pins by immersing them sequentially into various solutions of activated amino acids held in the wells of a microtiter plate. Houghten at The Scripps Research Institute in La Jolla synthesized a library of 260 peptides [10] in polypropylene mesh containers encapsulating polystyrene resin, a process that came to be known as the ‘‘tea-bag’’ strategy. Both the pin and the tea-bag techniques went on to gain wide popularity and led to new generations of improved technologies for combinatorial chemistry.
