By Mike S. Lee, Mingshe Zhu
This publication examines the history, commercial context, method, analytical technique, and expertise of metabolite identity. It emphasizes the functions of metabolite identity in drug examine. whereas essentially a textbook, the booklet additionally services as a accomplished connection with these within the undefined. The authors have labored heavily jointly and mix complementary backgrounds to deliver technical and cultural knowledge to this vitally important undertaking whereas helping tackle wishes inside academia and It additionally includes a number of challenge units following particular sections within the textual content.
Read or Download Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods) PDF
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Extra resources for Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods)
To avoid the formation of reactive, potentially toxic, metabolites) or to build “soft spots” into a structure to better control absorption, distribution, and elimination of a prodrug or drug. Finally, with the advent of methods to identify certain biotransformation genotypes and to characterize the phenotype of individual patients, drug therapy will become more individualized in order to decrease exposure to toxic metabolites in susceptible individuals. The purpose of this chapter was to survey the landscape of biotransformation reactions that can affect interindividual variation in drug efficacy and toxicity.
Its nucleophilic cysteinyl thiol group is involved in a number of reactions with electrophiles. GSH is present in high concentrations in most cells, and it can react nonenzymatically with highly reactive electrophiles. , 2005; Anders, 2004). There are two unrelated families of GSTs. The membrane-associated family of GSTs are involved in eicosanoid metabolism, and some microsomal forms do react with electrophilic substructures on drugs or their metabolites. 9 GLUTATHIONE CONJUGATION REACTIONS 37 substrate selectivities.
Glutathione transferases. Annu Rev Pharmacol Toxicol 2005;45:51À88. Kato R, Iwasaki K, Shiraga T, Noguchi N. Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes. Biochem Biophys Res Commun 1976;70:681À687. Kitamura S, Sugihara K, Ohta S. Drug metabolizing ability of molybdenum hydroxylases. Drug Metab Pharmacokinet 2006;21:83À98. Krueger S, Williams DE. Mammalian flavin-containing monooxygenases: Structure, genetic polymorphisms and role in drug metabolism.