By Christos S. Mantzoros
Foodstuff and Metabolism: Underlying Mechanisms and scientific effects brings jointly across the world well-known specialists to comprehensively evaluation our present knowing of the way meals interacts with the genetic substrate in addition to environmental-exogenous components, together with actual job or the shortcoming thereof, to bring about insulin resistance and the metabolic syndrome. After offering the scope of the matter, the 1st significant a part of the publication is dedicated to genetics and pathophysiology, the second one a part of the ebook offers the general public future health viewpoint of the main frequent difficulties linked to meals and the metabolic syndrome, while the 3rd significant a part of the ebook makes a speciality of scientific evaluation and administration of the most affliction states linked to beside the point food and the metabolic syndrome. ultimately, normal details worthwhile for either clinicians and researchers alike is gifted within the Appendix. nutrients and Metabolism: Underlying Mechanisms and medical effects bargains the reader an updated and authoritative evaluation of the main medical and medical elements of the overlapping components among meals and metabolism.
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Extra info for Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences (Nutrition and Health)
Example text
Deficiency of the insulin receptor substrate 1 protein (IRS-1) in mice results in postnatal growth retardation with only mild insulin resistance and no diabetes, whereas deletion of IRS-2 causes impaired insulin signaling and β-cell function, resulting in progressive deterioration of glucose metabolism (181,182). On the other hand, IRS-3 and IRS-4 knockout mice show respectively either mild glucose intolerance or have no phenotype, therefore suggesting that they are unlikely to play a major role in glucose homeostasis (183,184).
Examples of metabolic syndrome rodent models include the spontaneous hypertensive rat (SHR), the transgenic SHR overexpressing a dominant-positive form of the human sterol regulatory element binding transcription factor 1 (SREBP-1), the SHR/ Chapter 2 / Genes and Gene–Environment Interactions 17 NDmcr-cp rat, the polydactylous rat strain (PD/cub), the obese Zucker rats (OZR), the New Zealand obese (NZO), the Wistar Ottawa Karlsburg W rats, as well as congenic, consomic, and double-introgressed strains (93–100).
Proopiomelanocortin and energy balance: insights from human and murine genetics. J. Endocrinol. Metab. 2004; 89:2557–2562. 9. Clement K. Genetics of human obesity. Proc. Nutr. Soc. 2005; 64:133–142. 10. Harrold JA, Williams G. Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway. Peptides 2006; 27:365–371. 11. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 1998; 18:213–215.
