By Satomi Miwa, Kenneth Bruce Beckman, Florian Muller
Oxidative tension in getting older: From version structures to Human ailments discusses the function of unfastened radicals in getting older in numerous animal versions, in addition to the relevance of unfastened radicals on age-related illnesses and pathological stipulations in people (following an advent component to the fundamentals and idea of loose radicals). Human getting older is a posh phenomenon - now not all people will get a similar illnesses and dies from a similar reason. amassing experiences implicate the relationship among unfastened radicals and diverse illnesses and age-related pathological stipulations. even though the causal relationships haven't been confirmed, it is important to debate how unfastened radicals are inquisitive about every one state of affairs. additionally, the most important interventions trials of antioxidant supplementations in age-related disorder, melanoma etc are reviewed and discussed.
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Extra resources for Oxidative Stress in Aging: From Model Systems to Human Diseases
Example text
It is increasingly appreciated that protein aggregation plays a critical role in many (most prominently neurodegenerative) diseases [201]. The notion that ROS can contribute to protein aggregation has been long known, especially considering the role of ROS in formation of lipofuscin, the age pigment composed of aggregated, oxidized proteins and lipids [202, 203]. , α-synuclein (Parkinson’s disease) [204] and CuZnSOD (amyotrophic lateral sclerosis). It has been suggested that this is a key pathway by which oxidative damage contributes to aging [205].
Levine RL. Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue. J Biol Chem 1983;258(19):11823–7. 183. Levine RL, Oliver CN, Fulks RM, Stadtman ER. Turnover of bacterial glutamine synthetase: oxidative inactivation precedes proteolysis. Proc Natl Acad Sci U S A 1981;78(4):2120–4. 184. Requena JR, Chao CC, Levine RL, Stadtman ER. Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proc Natl Acad Sci U S A 2001;98(1):69–74.
Peskin AV, Low FM, Paton LN, Maghzal GJ, Hampton MB, Winterbourn CC. The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. J Biol Chem 2007;282(16):11885–92. 79. Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A 1987;84(16):5918–22. 80. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987;235(4792):1043–6.
