By Arti Hurria MD, Harvey Jay Cohen MD
The danger of melanoma raises with age, and the variety of older adults looking remedy is expanding dramatically in response to the getting older inhabitants. The care of older sufferers differs from that of more youthful adults due to alterations within the biology of the tumor, age-related adjustments in host body structure, comorbidity burden and psychosocial matters, which would im pact the efficacy and negative effects of melanoma treatment. useful Geriatric Oncology is a finished, evidence-based textual content that synthesizes the turning out to be literature during this box and gives functional directions to the care of older adults with melanoma. assurance contains sufferer evaluation, administration of reliable tumors and hematologic malignancies, the influence of age at the pharmacology of melanoma remedy, surgical oncology and radiation oncology within the older grownup, symptom administration, and supportive care. as well as serving as center examining for oncologists and hematologists, the ebook can be an invaluable paintings for different healthcare pros who offer oncology care, together with surgeons, radiation oncologists, palliative care medical professionals, fundamental care services, geriatricians, and nurses.
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Wildiers H, Paridaens R. Taxanes in elderly breast cancer patients. Cancer Treat Rev. 2004;30: 333–342. 31. Seidman AD, Berry D, Cirrincione C, et al. Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840. J Clin Oncol. 2008;26:1642–1649. 32. Lichtman SM, Hollis D, Miller AA, et al.
Brenner BM, Meyer TW, Hostetter TH. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982;307:652–659. 9. Muss HB, Woolf S, Berry D, et al. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. J Am Med Assoc. 2005;293:1073–1081. 10. Dixon DO, Neilan B, Jones SE, et al.
Hematological growth factors could help in maintaining dose intensity while decreasing hematological toxicity but do not alleviate nonhematological toxicities. 3). In a curative setting, such as lymphomas, dose intensity is critical and should be maintained if possible to optimize chances of cure. In an adjuvant setting, several studies suggest that low-dose or soft chemotherapy is associated with decreased efficacy. 12 A recent study showed that classical chemotherapy with doxorubicin and cyclophosphamide (AC) or CMF is superior to capecitabine, the latter being an oral drug incorrectly thought to be more easily manageable in elderly patients.
