By U.S. Department of Health and Human Services
This toxicological profile is ready in keeping with instructions constructed through the employer for poisonous ingredients and affliction Registry (ATSDR) and the Environmental security organisation (EPA). the unique directions have been released within the Federal sign in on April 17, 1987. every one profile should be revised and republished as precious. The ATSDR toxicological profile succinctly characterizes the toxicologic and hostile wellbeing and fitness results info for the poisonous elements each one profile describes. each one peer-reviewed profile identifies and stories the main literature that describes a substance's toxicologic houses. different pertinent literature is usually awarded yet is defined in much less aspect than the most important stories. The profile isn't meant to be an exhaustive rfile; in spite of the fact that, extra finished resources of strong point details are referenced. The profiles concentrate on health and wellbeing and toxicologic details; hence, every one toxicological profile starts off with a public wellbeing and fitness assertion that describes, in nontechnical language, a substance's proper toxicological homes. Following the general public health and wellbeing assertion is details touching on degrees of vital human publicity and, the place identified, major well-being results. A health and wellbeing results precis describes the adequacy of knowledge to figure out a substance's future health results. ATSDR identifies facts wishes which are major to security of public healthiness. each one profile: (A) Examines, summarizes, and translates to be had toxicologic info and epidemiologic reviews on a poisonous substance to envision the degrees of important human publicity for the substance and the linked acute, subacute, and persistent healthiness results; (B) Determines no matter if sufficient details at the wellbeing and fitness results of every substance is on the market or being constructed to figure out degrees of publicity that current an important chance to human future health of acute, subacute, and protracted wellbeing and fitness results; and (C) the place applicable, identifies toxicologic trying out had to establish the categories or degrees of publicity which could current major threat of difficult wellbeing and fitness results in people.
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Additional info for Toxicological profiles - Manganese
Sample text
Manganese, in its activating capacity, can bind either to a substrate (such as adenosine triphosphate, ATP), or to a protein directly, thereby causing conformational changes (Keen and Zidenberg-Cher 1990). , transferases, decarboxylases, hydrolases) (Wedler 1994). 4. Although manganese is an essential nutrient, exposure to high levels via inhalation or ingestion may cause some adverse health effects. dysfunction” that is dose-related (Mergler et al. 1999). In other words, mild or unnoticeable effects may be caused by low, but physiologically excessive amounts of manganese, and these effects appear to increase in severity as the exposure level increases.
Accurate information on dietary manganese contributions in future toxicity studies is necessary for more accurate calculations. A User's Guide has been provided at the end of this profile (see Appendix B). This guide should aid in the interpretation of the tables and figures for Levels of Significant Exposure and the MRLs. 1 Inhalation Exposure Inorganic manganese compounds are not volatile, but they can exist in the air as aerosols or suspended particulate matter. Table 2-1 and Figure 2-1 summarize the available quantitative information on the health effects that have been observed in humans and animals following inhalation exposure to various inorganic manganese compounds.
Enzymes that contain manganese include arginase, pyruvate carboxylase, and manganesesuperoxide dismutase (MnSOD) (Keen and Zidenberg-Cher 1990; NRC 1989; Wedler 1994). Manganese, in its activating capacity, can bind either to a substrate (such as adenosine triphosphate, ATP), or to a protein directly, thereby causing conformational changes (Keen and Zidenberg-Cher 1990). , transferases, decarboxylases, hydrolases) (Wedler 1994). 4. Although manganese is an essential nutrient, exposure to high levels via inhalation or ingestion may cause some adverse health effects.
