By Walter A. Korfmacher
Mass spectrometry (MS) is speedy changing into the top-rated software for reading numerous drug metabolism samples within the early stages of drug discovery and study. Introducing the more recent, extra robust MS apparatus and exploring new purposes for utilizing them, this e-book offers a cutting-edge examine this promising box. utilizing Mass Spectrometry for Drug Metabolism reports is a wonderful source for execs within the fields of mass spectrometry and drug metabolism. It bargains present wisdom in stand–alone chapters that handle particular subject matters completely adequate to be learn independently, with notes and references to different chapters for additional examining. the 1st 8 chapters speak about present themes concerning the use of MS for studying a variety of sorts of in vitro and in vivo drug metabolism samples and the ultimate 4 chapters describe the most recent MS expertise and its makes use of. In each one bankruptcy, specialist authors display tips on how to observe MS to figure out drug metabolism parameters. in addition they clarify different drug metabolism thoughts and their value. even supposing there are a number of books presently out there that handle this subject, they're quickly changing into out-of-date. This booklet provides drug researchers and pharmacokineticists the newest info to be had in this vital expertise.
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Extra resources for Using Mass Spectrometry for Drug Metabolism Studies
Sample text
Before the development stage, one could envisage a series of assay requirements that become stricter as one approaches the development stage. 18, various levels (I–IV) have been assigned to the stages leading up to and including the development stage. 2, these drug stages have been assigned assay types (level I to level IV). level I is the screening stage, level II is lead optimization, level III is lead qualification and level IV is development. Screening can be defined as the stage where a larger number of compounds are tested in order to select a smaller number for optimization.
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792(2), 229, 2003. 86. A. et al. HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process, Drug Discov. Today, 2, 532, 1997. 87. A. et al. Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery, Rapid Commun. , 15(5), 335, 2001. 88. Z. et al. Development and validation of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of ribavirin in human plasma and serum, J.
