By Walter A. Korfmacher
The 1st variation of this now vintage paintings helped to set up mass spectrometry because the most desirable instrument for drug metabolism stories. thoroughly rewritten from begin to end, utilizing Mass Spectrometry for Drug Metabolism reviews, moment version brings medicinal chemists and mass spectrometry pros in control with the quick advances within the box, the emergence of state-of-the-art methods, and how you can meet progressively expanding seller calls for. Written by way of overseas scientists who're specialists of their respective disciplines, this state of the art reference successfully encapsulates present mass spectrometry top practices. The stand-alone chapters conceal quite a few issues – from metabolite id to speedy chromatography with UPLC – and in a mode that's comprehensible to specialists and box rookies alike. the second one version of this bestseller contains insurance of latest instrumentation and software program in addition to a wealth of up-to-date details at the newest findings surrounding biomarkers and metabolomics and new chapters on either UPLC and DESI/DART. With greater than one hundred eighty illustrations and an eight-page colour insert, this beneficial reference explores a number of glossy mass spectrometry ideas and methods. It contains a very good evaluation of the total drug discovery technique plus the most recent advancements on how mass spectrometry is used to aid this activity.
Read Online or Download Using Mass Spectrometry for Drug Metabolism Studies, Second Edition PDF
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Extra resources for Using Mass Spectrometry for Drug Metabolism Studies, Second Edition
Example text
102. F. , Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice, Cancer Chemother. , 54(6), 475, 2004. 103. A. , Cassette-accelerated rapid rat screen: A systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery, Rapid Commun. , 15(5), 335, 2001. 104. , 8(3), E493, 2006. 105. Liu, B. , Snapshot PK: A rapid rodent in vivo preclinical screening approach, Drug Discov.
Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: Practical approaches to their elimination, Rapid Commun. , 17(17), 1950, 2003. 110. C. , Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring informationdependent acquisition on a QTrap instrument, Rapid Commun. , 19(14), 1943, 2005. 111. Z. , A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer, J.
Wainhaus, S. , Ultra fast liquid chromatography-MS/MS for pharmacokinetic and metabolic profiling within drug discovery, Am. , 2(1), 6, 2007. 108. , Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS, Anal. , 75(13), 3019, 2003. 109. Schuhmacher, J. , Matrix effects during analysis of plasma samples by electrospray and atmospheric pressure chemical ionization mass spectrometry: Practical approaches to their elimination, Rapid Commun. , 17(17), 1950, 2003.
