Download PDF by Angelo Albini, Elisa Fasani, Royal Society of Chemistry: Drugs, photochemistry and photostability

By Angelo Albini, Elisa Fasani, Royal Society of Chemistry (Great Britain)

Seeing that Pasteur in 1846, scientists were conscious that many medicines are photoreactive, yet until eventually lately learn during this zone were a little restricted. even if, because the advent of acutely delicate analytical equipment, the realisation of the necessity to determine the photochemical houses of a possible drug as early in its improvement as attainable and the elevated cognizance to the phototoxic impact of gear, extra info have gotten on hand. medicines: Photochemistry and Photostability offers the fundamental parts of the technological know-how, and serves as a very good creation to this rising box of photochemistry. certain experimental stipulations for photostability experiences are given, besides a dialogue of the lately carried out ICH guidance for drug photostability. With contributions from overseas specialists within the box and together with a entire literature assessment, this publication offers the entire up to date details wanted via researchers in lots of fields, specially medicinal and pharmaceutical chemistry.

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Irreversiblebinding to the carbohydrate, however). Other additives act not on the excited state per se, but rather on the primary product, be it a ground state molecule or a reaction intermediate. These are converted back to the starting material. Reducing agents have been used for this purpose. ~5~ It may be that PABA acts not only as an internal filter (see above) but also interfereswith the photoreaction in a similar way. Another mechanism of action is formation of a complex between the additive and the ground state of the drug, when such complex is less photolabile than the original substrate.

Encyclopedia of Pharmaceutical Technology, Dekker, New York, 1995, Vol. 12, p. 105. 15. T. Oppenlaender, Chimia, 1988,42,331. 16. H. H. Tlannesen and J. Carlsen, Pharmeuropa, 1995,7, 137. 17. H. H. 371. 18. F. Vargas, C. Rivas, M. A. Miranda and F. Bosca, Pharmazze, 1991,46,767. 19. E. Moore and P. P. Chappuis, Photochem. , 1988,47, 173. 20. G. Condorelli, G. De Guidi, G. Giufida and L. L. Costanzo, Coord. Chem. Rev. 1993, 125, 115. 21. D. Budac and P. Wan,J. Photochem. , 1992,67, 135. 22. K.

87 32 Drugs: Photochemistry and Photostability Product (191) in turn undergoes secondary photoreactions involving the known redox chemistry of this compound, and leading to amino and nitrosobenzoic acid, the corresponding azoxy derivative, as well as to aminobenzaldehyde. 188-190 Further aromatic derivatives for which photolability has been reported include the antihepatitis drug catechin (cyanidol, 192). H ‘ & C H 2 3 C1 c1. 3 /3-Lactam Antibiotics. In compounds containing an oxime knction such as aztreonam (199195 and cefotaxime (19 6 ) p syn-anti isomerisation occurs rapidly upon irradiation (thus diminishing the pharmacologicalactivity), and is accompanied by degradation processes.

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